Cognitive Support. Lion’s Mane is a very well known nootropic known for its ability to assist with NGF (nerve growth factor) production and protection. Components and extracts of Lion’s Mane have proven antibiotic, anticancer, neuroprotective, fat- and glucose-lowering effects. This mushroom is also known to protect against stomach ulcers, reduce anxiety and depression, aid cognitive function, and has anti-fatigue and anti-aging properties. All of these beneficial effects are based on three important properties of this mushroom: it decreases inflammation, acts as an antioxidant, and stimulates the immune system.